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KMID : 0370219830270030207
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Yakhak Hoeji
1983 Volume.27 No. 3 p.207 ~ p.213
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Pharmaceutical Studies on the Esterification of Chloramphenicol with Antipyretics (I)
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김정우/Kim JW
김종갑/Kim JK
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Abstract
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Chloramphenicol (CAF) was esterified with aspirin, naproxen and acetaminophen in order to develop new prodrugs which have double effect-antibiotic activity and antipyretic effect. Chloramphenicol acetylsalicylate (CAF-ASP), chloramphenicol naproxenate (CAF-NAX), and chloramphenicol acetaminophen succinate (CAF-SUC-ACET) were synthesized by using dicyclohexylcarbodiimide (D.C.C.) because of two hydroxyl group of chloramphenicol. Three synthetic prodrugs did not show bitterness and antibiotic activity in vitro, and were hydrolyzed in liver homogenate, but weren’’t in acid.
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KEYWORD
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